PFIM
General software features
PFIM (Population Fisher Information Matrix) is a R function dedicated to evaluation and optimisation of designs (number of subjects, number of samples per subject and their allocation in time) for nonlinear mixed effects models (population approach). This function is based on the developpement of an approximation of the Fisher information matrix in these models.
Two latest versions of PFIM are currently available :
- a graphical user interface package using the R software (PFIM Interface 3.1),
- an R script version (PFIM 3.2.2) requiring some knowledge in R use but which benefits of the latest methodological developments performed in the research team.